For more info about our products, complete the form below:

Sticky: The difference between steroid abuse and hormone replacement therapy.

Sticky: The difference between steroid abuse and hormone replacement therapy.

June 20, 2014

Adverse Effects of Anabolic Steroid Abuse vs. Benefits of Physician- Supervised Hormone Replacement Therapy (HRT)

Due to an increase in media coverage of sports and athletes regarding non-medical use of anabolic steroids, the difference between hormone replacement therapy and anabolic steroids has become confusing to the general public. Young athletes illegally take synthetic male anabolic steroids without a physician’s supervision because they wish to increase their physical stamina for enhanced athletic performance. This is done through tissue building effects and an increase in male physical characteristics, desired by both male and female athletes alike.  Synthetic anabolic steroids mimic the effects of the male sex hormone, testosterone, which can increase muscle mass and strength in short periods of time.

Steroids are no stranger to the fitness/bodybuilding world and competitive athletics, but today more and more “regular guys” are taking steroids in an effort to combat the effects of aging and reduce its impact. While legal steroids do have a place and serve useful, medically-valid purposes, they are frequently abused. Part of this stems from their widespread availability in gyms, health clubs, online from Internet pharmacies, friends and more.

Besides being illegal without a prescription, steroids – when taken without proper medical supervision – are known to cause a variety of health problems. The short-term adverse physical effects of anabolic steroid abuse are fairly well known, but the effects of their long-term use are not well-studied. Abuse or overuse of synthetic anabolic steroids may cause the male body to become “feminized,” causing irreversible physical and psychological damage – depending on the dosage, type of synthetic steroid being taken, and usage duration. Some examples are high blood pressure, serious changes in cholesterol levels, heart problems in the left ventricle, and liver damage if oral steroids are taken. In this sense, the difference between hormone replacement therapy and anabolic steroids has a lot to do with non-medical versus medical use, and the illegal use of a synthetic form of testosterone versus legal use of pure testosterone.

The real problems arise when steroid users become steroid abusers. They buy their steroids at the gym or from a friend, self-administering them and regulating their intake themselves, rather than under the guidance of a trained medical professional. This is a recipe for disaster. When someone buys steroids off the black market the potential for dangerous repercussions is astronomical.

First of all, when buying steroids off the black market, you never really know what you are going to get. The majority of steroids sold on the streets in the U.S. come from other countries where quality standards can be very lax at best. It’s also very common to take steroids prepared for animals rather than for humans because they are usually cheaper-but also potentially very dangerous. There is also a prevalence of fake or counterfeit steroids on the U.S. black market. These can not only be dangerous, but they can be deadly as well.  The only benefit of using an anabolic steroid is when it is prescribed medically for medical conditions, the same as hormone replacement therapy. In certain medical cases, it is the only answer for quality life. The main difference between hormone replacement therapy and anabolic steroids comes down to how each is used, specifically if it is used under proper medical supervision.

There’s no getting around the fact that our bodies age. For men, as we get closer to the middle age mark, natural testosterone production in the body begins to slow down by about one to two percent each year – though this can vary widely. Around age 50 or so, about one-half of men will experience what’s known as “andropause,” which is the result of declining levels of androgen in the body. The symptoms of andropause will vary from one man to another but may include a decrease in energy (lethargy), diminished libido or less interest in sex, erectile dysfunction (ED), muscle weakness, difficulty sleeping, hot flashes, night sweats, mood swings or depression and more. Because of the symptoms’ similarity to what women experience in menopause, andropause is sometimes referred to as the “male menopause,” although in men the reproductive system does not shut down entirely as it does in women – it just slows down.  To fight the symptoms of andropause many men turn to either steroids or hormone replacement therapy (HRT).

Hormone replacement therapy (HRT) is practiced under a physician’s care and is medically used for abnormal testosterone levels in menopausal individuals, chronic wasting diseases, and to treat a multitude of symptoms. Hormone replacement therapy also does not use a synthetic steroid, but a pure form of testosterone. It is used under physician care for many medical benefits. The goal of hormone replacement therapy is to keep abnormal hormone levels normal and to treat certain medical conditions, not to build muscles and strength. Hormone replacement therapy has been used for reductions of heart disease, abnormal cholesterol levels, high blood pressure, strokes, type-2 diabetes, and early death. In fact, the use of testosterone in hormone replacement therapy has improved the lives of a many aging men. Previously they were diagnosed with no sex drive, with erectile dysfunction, extreme fatigue, irritability, a serious loss of energy, and felt their life was going nowhere.

In contrast to self-regulated/self-administered steroid abuse, Hormone Replacement Therapy (HRT) is a medically supervised regimen that seeks to duplicate the body’s natural testosterone production cycles. Administered properly, HRT can bring about the benefits of restoring testosterone to its previous level, without the significant side effects or safety hazards associated with self-regulated/self-administered steroid regimens or abuse. HRT starts with a blood test and medical examination to determine testosterone levels and uncover any potential health risks. This is an important-and necessary–step in order to be certain that testosterone deficiency is indeed the root of the andropause symptoms and not diabetes, hypertension or the result of taking certain medications.

Through HRT testosterone is administered orally, by injection or through trans-dermal systems (through the skin). A fourth method-a tablet that adheres to the surface of the gum-was recently approved by the FDA. HRT has proven beneficial to men suffering from symptoms of andropause resulting from a testosterone deficiency in a number of ways including:

Increasing sex drive

Increasing muscle mass

Increasing strength

Improving mood

Increasing bone density

These are just some of the benefits that are associated with a properly-administered, medically-supervised HRT regimen. Once treatment begins, HRT recipients are monitored for possible side effects or adverse reactions to the treatment. Generally though, this is not the case. The overwhelming majority of HRT recipients are very satisfied with the results, generally reporting few, if any, negative side effects or consequences. While many of us like to think that we’re smart guys and know what we’re doing with our own bodies, the risks associated with self-administered/self-regulated steroid regimens far outweigh any potential benefits. And in addition, the potential for abuse is great. If you think you may be suffering from andropause/testosterone deficiency, do yourself a favor and consult a qualified medical professional and investigate hormone replacement therapy as a treatment, not your friends at the gym.




Hormone Replacement Therapy Clinic of Florida

Hormone Replacement Therapy Clinic of Florida

January 5, 2013

Hormone Replacement Therapy

Many men could benefit from testosterone replacement therapy to combat common health issues men experience every day. However, there are many men that dismiss these issues as inevitable signs of aging. There is a common misconception many men may have about hormone replacement therapy: that it is strictly for women.

The truth is that hormone replacement therapy can help men live more youthful, energetic lives, and slow down those inevitable signs of aging. In recent men’s health research, many men reported several common physical and emotional symptoms often attributed to aging and low testosterone. Some common symptoms of male menopause are as follows:

Lower Libido
Lower Energy Levels
Lower Muscle Mass
Lower Strength
Lower Stamina
Erectile Dysfunction
Osteoporosis
Heart Disease
Sleep Disorders
Depression & Anxiety

Symptoms of andropause, or male menopause, a condition marked by a decrease in testosterone levels or an increase in estrogen levels. These symptoms may respond favorably to hormone replacement therapy offered by Core Medical Group.

As more men are learning about the benefits of hormone replacement therapy, more and more hormonal supplements are turning up in the marketplace. Too often however, these supplements are the mass-produced, one-size-fits-all variety that doesn’t consider the man’s individual, unique biological needs. That’s why more men are turning to Core Medical Group for their customized approach of addressing male hormonal deficiencies.

Hormone Replacement Therapy Care for Men

Core Medical Group physicians and staff specialize in a variety of custom BHRT supplements & wellness solutions for our male patients. Working directly with you and our accredited compounding pharmacist, our physician will help to determine the exact formulation to best fit your needs. Hormone Replacement Therapy formulations offered by Core Medical Group are as follows:

Capsules or tablets for ingestion
Injections
Flavored drops or troches that dissolve in the mouth
Topical creams or lotions applied to the skin
Hormone Pellet Therapy

Custom Hormone Replacement Therapy Care by Core Medical Group

At Core Medical Group we work with only accredited compounding pharmacists to formulate the best treatment for your individual needs. You can depend on us to stay with you, monitoring your treatment and helping you each step of the way. So give us a call! We’re eager to begin helping you achieve your wellness goals today!

 




Danazol

Danazol

August 26, 2011

Drug Reference Information

Dosage
Usual Adult Dose:
100 mg to 200 mg orally two times a day.

Severe cases of endometriosis may require an initial dosage of 400 mg orally two times a day.

To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non-hormonal birth control method is recommended.

Following an initial favorable response (amenorrhea develops), the dosage should be titrated to the minimum dose that suppresses disease activity.

Therapy should continue uninterrupted for 3 to 6 months. Administration of danazol up to 9 months may be necessary. Should symptoms recur, danazol treatment may be reinitiated.50 mg to 200 mg orally two times a day.

To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non-hormonal birth control method is recommended.

Resolution of pain and tenderness usually occurs following 1 to 3 months of therapy. Elimination of nodules often requires 4 to 6 months of uninterrupted therapy. Symptoms recur within one year in 50% of patients and therapy may be reinitiated if necessary.200 mg orally two to three times a day.

To assure a female patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non-hormonal birth control method is recommended.

Following an initial favorable response (prevention of edematous episodes), attempts should be made at 1 to 3 month intervals to reduce the dosage to the minimum continuous dose that will prevent angioedema. Dosage reductions up to 50% per interval may be considered. Should angioedema recur, the daily dosage may be increased up to 200 mg.

Warnings
Danazol is contraindicated in patients with severe renal or hepatic dysfunction, acute intermittent porphyria, or in women who are suspected or known to be pregnant, who are nursing, or have undiagnosed abnormal genital bleeding.

Thromboembolic and thrombophlebotic events (including sagittal sinus thrombosis), some resulting in fatal strokes, have occurred.

Life-threatening peliosis hepatis and benign hepatic adenoma have occurred following prolonged danazol administration.

Benign intracranial hypertension (pseudotumor cerebri) has been reported.

The pituitary-suppressive actions of danazol are reversible. Ovulation and cyclic bleeding usually return in 2 to 3 months following discontinuation of danazol.

Side Effects
Cardiovascular side effects have included edema and congestive heart failure.Endocrine side effects have included the inhibition of estrogen synthesis, resulting in flushing, sweating, vaginal dryness and irritation, and reduction in breast size. During administration of danazol, endogenous testosterone synthesis and release may be inhibited through feedback inhibition of pituitary luteinizing hormone (LH). Large doses of danazol may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone (FSH). Danazol may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction.Gastrointestinal side effects have included nausea and vomiting. Rare cases of pancreatitis have been reported.Genitourinary side effects have included oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop.

In female patients, the use of danazol may result in virilization including deepening voice, hirsutism, acne, clitomegaly (rare), and menstrual abnormalities. Discontinuation of medication at signs of mild virilization may prevent irreversible virilization.

Alterations in libido may occur (increased/decreased).Hematologic side effects have included thromboembolic and thrombophlebotic events (including sagittal sinus thrombosis), some resulting in fatal strokes, and increased red cell production.Metabolic side effects have included significant increases in low density lipoproteins (LDL) and decreases in high density lipoproteins (HDL). Decreased glucose tolerance requiring adjustments in hyperglycemic control has occurred.Other side effects in female patients have included virilization, including deepening voice, hirsutism, acne, clitomegaly (rare), and menstrual abnormalities, due the androgenic activity of danazol. Discontinuation of danazol at signs of mild virilization may prevent irreversible virilization. Reduction in breast size may occur due to decreased estrogen synthesis.Renal side effects have included the retention of nitrogen, sodium, potassium, chloride, water and phosphorus, and decreased urinary excretion of calcium.Oncologic side effects have included rare cases of hepatic neoplasms following prolonged use.Hepatic side effects have included life-threatening peliosis hepatitis and benign hepatic adenoma following prolonged danazol administration. Rare cases of hepatic neoplasms following prolonged use have been reported. Danazol can exacerbate acute intermittent porphyria. Serum transaminase levels may be increased.

Pregnancy
Danazol has been assigned to pregnancy category X by the FDA. Animal (rat) studies using danazol at doses 7 to 15 times that of a corresponding human dosage on days 6 to 15 of gestation failed to reveal evidence of teratogenicity or embryotoxicity. Studies in rabbits during days 6 to 18 of gestation at doses 2 to 4 times that of a corresponding human dosage resulted in inhibition of fetal development. There are no controlled data in human pregnancy. Danazol use is considered contraindicated during pregnancy.

Reversible oligospermia may occur in adult males after prolonged administration or excessive dosage. If this effect occurs, danazol can be discontinued and if restarted, a lower dosage should be utilized.If therapy is not initiated during menstruation, a sensitive pregnancy test that detects early pregnancy should be done to determine that the patient is not pregnant. A non-hormonal contraceptive method should be used during danazol therapy. If pregnancy occurs during therapy, danazol should be discontinued. Patients should be advised of the possible risks to the fetus.

Lactation
There are no data on the excretion of danazol into human milk. Breast-feeding is considered to be contraindicated by the manufacturer.

Pharmacology
Pharmacology:

Danazol, a synthetic androgen, is derived from ethisterone.

Danazol inhibits pituitary release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) resulting in reduced gonadal (sex) steroid synthesis. Danazol may directly inhibit sex steroid synthesis and competitively inhibits sex steroid binding to intracellular target tissue receptors. Suppression of ovarian function induces endometrial inactivity and atrophy. Danazol decreases IgG, IgA, IgM, and autoantibodies levels in patients with endometriosis.

Danazol exerts weak dose-related androgenic activity. Androgenic activity induces normal growth and development of male sex organs, maintains secondary sex characteristics, and modulates the growth spurt of adolescence and eventual termination of linear growth.

Danazol increases serum concentrations of C1 esterase inhibitor (C1 IHN) which results in increased concentrations of the C4 component of the compliment system.

Danazol is FDA approved for treatment of endometriosis and fibrocystic breast disease. It is also indicated for use in prevention of attacks of hereditary angioedema.

Danazol has been used in treatment of gynecomastia, menorrhagia, and precocious puberty. It has also been used in female or male contraception, breast cancer, certain anemias (red cell aplasia and other deficient red cell production anemias) to enhance red cell production, as treatment in select coagulopathies (Antithrombin III deficiency or fibrinogen excess), in inflammatory responses (autoimmune hemolytic anemia, asthma, SLE) and to modulate growth failure (primary or secondary) or short stature associated with Turner’s syndrome.

Pharmacokinetics:

Danazol is available for oral administration.

Danazol is rapidly and almost completely absorbed. Peak levels occur within 2 hours. Bioavailability is increased when danazol is taken with food (especially fatty foods), however, the time to peak concentration is delayed approximately 30 minutes.

Dosage increases do not produce proportional increases in danazol serum concentrations. Doubling the dose increases serum concentrations only 35% to 40%.

The plasma protein binding of danazol is unknown.

The volume of distribution of danazol is unknown.

The apparent total body clearance is 710 L/hour.

The elimination half-life averages 9.44 hours.

Danazol is metabolized to various metabolites. Six metabolites have been identified. Ethisterone appears to be an active metabolite and possesses progestational and mildly androgenic activity. Danazol undergoes extensive enterohepatic circulation. Danazol is found primarily in the adrenals and kidneys. Danazol is excreted by the kidneys (50%) and to a lesser extent in the feces (36%).

There are no data on the pharmacokinetic disposition of danazol in patient with renal and/or hepatic dysfunction.

There are no data on the hemodialysis or peritoneal dialysis clearance of danazol.




Estrogen Test

Estrogen Test

An estrogen test measures the level of the most important estrogen hormones (estradiol, estriol, and estrone) in a blood or urine sample.

  • Estradiol is the most commonly measured type of estrogen for nonpregnant women. The amount of estradiol in a woman’s blood varies throughout her menstrual cycle. After menopause, estradiol production drops to a very low but constant level.
  • Estriol levels usually are only measured during pregnancy. Estriol is produced in large amounts by the placenta, the tissue that links the fetus to the mother. It can be detected as early as the 9th week of pregnancy, and its levels increase until delivery. Estriol can also be measured in urine.
  • Estrone may be measured in women who have gone through menopause to determine their estrogen levels. It also may be measured in men or women who might have cancer of the ovaries, testicles, or adrenal glands.

Both men and women produce estrogen hormones. Estrogens are responsible for female sexual development and function, such as breast development and the menstrual cycle. In women, estrogens are produced mainly in the ovaries and in the placenta during pregnancy. Small amounts are also produced by the adrenal glands. In men, small amounts of estrogens are produced by the adrenal glands and testicles. Small amounts of estrone are made throughout the body in most tissues, especially fat and muscle. This is the major source of estrogen in women who have gone through menopause.

For pregnant women, the level of estriol in the blood is used in a maternal serum triple or quadruple screening test. Generally done between 15 and 20 weeks, these tests check the levels of three or four substances in a pregnant woman’s blood. The triple screen checks alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and a type of estrogen (unconjugated estriol, or uE3). The quad screen checks these substances and the level of the hormone inhibin A. The levels of these substances-along with a woman’s age and other factors-help the doctor estimate the chance that the baby may have certain problems or birth defects.




Lipotropic Injections

Lipotropic Injections

What Does Lipotropic Mean?

Lipotropic compounds are substances that help stimulate the breakdown of lipid (fat) during metabolism and, in this way, reduce the accumulation of excess fat in the liver and other tissues. Injections of carefully calibrated doses of natural lipotropic nutrients can optimize your ability to shed fat.

Lipotropic Injections Improve Weight Loss

Many substances have lipotropic properties. The most effective lipotropic agents for weight loss purposes are choline, inositol and methionine. Through their involvement in lipid (fat) metabolism, lipotropic agents help maintain a healthy liver. The liver plays a major role in human metabolism including aiding in the digestion, storage, and distribution of nutrients and the detoxification of metabolic poisons and waste products.

The liver produces and stores glycogen from excess carbohydrates, and later releases it when blood sugar levels fall too low. The liver synthesizes plasma proteins that carry oxygen and nutrients to the body tissues and plasma proteins that carry waste products back to the liver for detoxification. The liver also produces bile, a compound that emulsifies fat so that it can be broken down by digestive enzymes. A lipotropic nutrient is one that promotes or encourages the export of fat from the liver. Lipotropics are necessary for the maintenance of a healthy liver as well as burning the exported fat for additional energy. Without lipotropics such as choline and inositol, fats and bile can become trapped in the liver, causing severe problems such as cirrhosis and blocking fat metabolism. Choline is essential for fat metabolism. Choline functions as a methyl donor and it is required for proper liver function. Like inositol, choline is a lipotropic. Inositol exerts lipotropic effects as well. An “unofficial” member of the B vitamins, inositol has even been shown to relieve depression and panic attacks. Methionine, an essential amino acid, is the major lipotropic compound in humans. When estrogen levels are high, the body requires more methionine. Estrogens reduce bile flow through the liver and increase bile cholesterol levels. Methionine helps deactivate estrogens.

Vitamin B12

This vitamin is important to keep the brain and nervous system functioning normally and for the formation of red blood cells. By synthesizing and regulating DNA, B12 is involved in cellular metabolism. It also plays a vital role in fatty acid synthesis and energy production. Many medications, certain medical conditions, and the normal aging process can lead to a B12 deficiency.

Choline and Inositol

These chemicals are co-enzymes that are required for the proper metabolism of fats and have the ability to remove fat from the liver. Since brain and nerve cells have a protective covering made of fatty acids, choline and inositol are necessary for normal nerve and brain function.

Choline is a key agent in bile production, and bile emulsifies fats in foods you eat so they can be digested. Without choline, fats can become trapped in the liver, where they can block normal metabolic functions. Choline also helps to emulsify cholesterol so that it mixes with the blood and does not settle on the walls of the arteries.

Choline works in combination with inositol to metabolize fats and cholesterol. The body can produce choline, with the help of vitamin B12, folic acid (vitamin B9) and the amino acid known as methionine. However, the rate your body produces choline may not be adequate to meet daily metabolic needs, particularly during weight loss when a lot of body fat must be broken down. Studies show that diets deficient in choline often result in undesirable changes to liver, kidney and brain functions. For this reason, we often recommend choline injections to our weight loss patients.

Inositol is a member of the B-Complex vitamin group and is a lipotropic agent. It metabolizes fats and cholesterol and helps transport fats in the blood system. Thus, inositol can aid in the redistribution of body fat and can help to lower cholesterol levels by moving cholesterol to the liver where it can be excreted. A lack of inositol has been shown to result in an accumulation of triglycerides (a fat compound made of 3 fatty acids) in the liver.

Methionine

This chemical is an essential amino acid that participates in fat and protein metabolism. It has lipotropic properties similar to those produced by choline. Methionine is an essential amino acid because your body cannot produce it. It must be supplied by your diet. Your body uses methionine to make proteins and many other important substances. For example, your body requires an adequate supply of methionine to synthesize two other important amino acids cysteine and taurine. Methionine is also one of the nutrients required for the body to produce choline. Therefore, a deficiency of this amino acid will adversely affect fat metabolism by limiting choline production. Methionine levels also affect the amount of sulfur-containing compounds, such as glutathione, in the liver. Glutathione and other sulfur-containing peptides (small proteins) play a critical role in defending against toxic compounds. When higher levels of toxic compounds are present, more methionine is needed.




10 reasons for Hormone Replacement Therapy (HRT) Clinic

10 reasons for Hormone Replacement Therapy (HRT) Clinic

August 15, 2011
(1). HRT will stop your hot flushes and sweats

Troublesome hot flushes, severe night sweats and headaches causingchronic insomnia are characteristic symptoms of the menopause.These symptoms may last for many years. Apart from being sociallyembarrassing they result in tiredness and depression becauseof lack of sleep. These symptoms can almost invariably be curedwith the correct small dose of estrogen. Although selectiveserotonin reuptake inhibitor antidepressants have been suggestedfor the treatment of vasomotor symptoms, no other treatmentis nearly as effective as estrogens. Women who still have auterus should still have 7–12 days of progestogen in orderto produce a withdrawal bleed and prevent endometrial hyperplasia.

(2). Estrogens will treat vaginal dryness and many causes of painful intercourse and lack of libido

Thinning of the pelvic tissues producing vaginal dryness andoccasionally bleeding is another characteristic result of estrogendeficiency that occurs after the menopause. This also can besuccessfully treated with estrogen either by tablets or throughthe skin by patches or gels or implants. Transdermal estrogentherapy is probably the safest and most effective route as hepaticcoagulation factors are not stimulated. Local estrogens canalso be given for this symptom using local vaginal applicationsof weak estrogens such as oestriol that are hardly absorbed.Other related problems of painful intercourse, loss of libidoand recurrent ‘cystitis’, if due to pelvic atrophyare also effectively treated by systemic or long-term localvaginal estrogens.

(3). HRT increases bone density and prevents osteoporotic fractures

Every study confirms that estrogens are the most effective wayof increasing bone density and preventing osteoporotic fractureseven in low-risk women. This treatment is very safe when startedin women under the age of 60. It is more effective and beneficialthan the bisphosphonates that are frequently used by bone physiciansas first choice and by general practitioners unsure about thesafety of estrogen therapy. These non-hormonal drugs with theirconsiderable long-term complications should have no place inmaintaining bone density in women under the age of 60. For therecently menopausal women receiving estrogen therapy for climactericsymptoms such as flushes, sweats or vaginal dryness, there willbe a considerable increase, up to 15% in 10 years to such anextent that osteoporotic fractures 20 years later in the olderwomen are much less likely to occur. If these women have lowbone density, even without typical menopausal symptoms, estrogensmust be seen as first-choice therapy. For those younger womenwith severe osteopenia or osteoporosis due to premature menopause,early hysterectomy and oophorectomy or anorexia with amenorrhoea,estrogens are an essential long-term treatment.

(4). HRT protects the intervertebral discs

Important recent studies from several centres have shown conclusivelythat estrogens prevent collagen being lost from the intervertebraldiscs, thus maintaining their strength and function. These discsmake up one-quarter of the length of the spinal column and actas cushions preventing crush fractures of the vertebral bodies.It is these crush fractures that lead to loss of height andthe lordosis of the upper spine known as the Dowager’s hump.This important protective effect of estrogens seems to be uniqueas bisphosphonates and the other non-hormonal treatments oflow bone density do not have any beneficial effect upon thediscs. {As pointed out elsewhere bisphosphonates increase bone density by going to the bond long-term, but done make the bones more resistant to fractures–jk}.

(5). HRT does reduce the number of heart attacks

There are about 30 years of evidence from many observationaltrials that estrogens reduce the incidence of coronary heartdisease. This has subsequently been questioned by the 2002 WHIStudy, which showed an increase in heart attacks. However, thisstudy looked at patients of the wrong age and who were usingthe wrong dose of estrogen and progestogen. Subsequent reportsfrom the same investigators have shown a very much reduced incidenceof heart attacks in women who start HRT below the age of 60.This is particularly apparent in women who have had a hysterectomyand can have estrogens without progestogen. The view now isthat HRT, particularly estrogen alone, is very safe and is associatedwith a reduced number of heart attacks if started below theage of 60. Thus there is primary prevention of coronary heartdisease, but there is no evidence of protection in women withestablished coronary damage.

It would appear that the factor that is associated with theapparent increase in severe side-effects such as breast cancerand heart attacks and possibly stroke is the progestogen componentof HRT. As progestogen also produces unwanted PMS-type side-effectsof depression, anxiety, bloating and loss of libido in patientswho are progestogen intolerant, it is sensible to keep the doseof oral gestogen to a minimum. The alternative is to inserta Mirena intrauterine system, which produces amenorrhoea andavoids the use of oral progestogen with its side-effects forfive years or more.

(6). Estrogens help depression in many women

Estrogens are more effective in the treatment of depressionin premenopausal or perimenopausal women than post- menopausalwomen. However there is no doubt that depression is helped inpostmenopausal women who have been suffering from night sweats,insomnia or vaginal dryness, painful intercourse and maritalproblems in that most of these problems can be effectively treatedand removed. However, it is true that the most impressive effecton mood is seen in younger perimenopausal women in the 2–3years before the period cease in the menopausal transition.This cannot be diagnosed by blood tests but by a careful history.This depression often occurs in women who are sensitive to abruptchanges in their hormones, either endogenous oestradiol or progesterone.These women had previously had postnatal depression and premenstrualdepression in what should be known as reproductive depression.They often also have cyclical headaches/migraines that occurwith the cyclical hormonal fluctuations at menstruation. Aspremenstrual depression becomes worse with age, it blends intothe more severe depression of the transition phase and is veryeffectively treated by moderately high-dose transdermal estrogensused by patches, gels or implants.

(7). HRT improves libido

HRT certainly improves libido if estrogens are used to curevaginal dryness and painful intercourse. Even without thesecharacteristic symptoms, estrogens can improve sexual desire.However, if necessary, the addition of testosterone has a moredramatic effect upon libido, frequency of intercourse and intensityof orgasm. Testosterone patches licensed in women after hysterectomyand testosterone gels in the appropriate dose are often andshould be used ‘off license’ with full consent andexplanation.

Women must be aware that testosterone is not only a male hormonebut it is an essential female hormone present in women in about10 times the blood levels as estrogen. It is an essential hormone,important for energy, mood and sexuality.

(8). HRT improves the texture of the skin

After the menopause, women lose about 25% of their body collagen,which is manifested by thin inelastic skin, brittle nails, lossof hair and loss of the collagenous bone matrix. This latterloss is an essential cause of osteoporosis and osteoporoticfractures. Estrogen therapy replaces the lost collagen in theskin and the bone. Its affect on the facial skin is a very obvioususeful cosmetic effect.

(9). ‘I am a nicer person to live with’

This is a quote from a patient. Many women say that when estrogentherapy stops their depression, their loss of libido and theirirritability, they become more agreeable people for their partnersto live with. The depression, irritability, grumpiness and lossof energy and disinterest in sex can usually be improved considerablyby the appropriate doses of the appropriate hormones that mayinclude testosterone as well as estrogen.

(10). HRT is safe

In spite of the press reports stressing bad news, virtuallyall claims of major adverse effects from the WHI study havebeen reconsidered even by the investigators. It seems quiteclear that the reported major side-effects of breast cancer,stroke and heart attacks occurred in women who started the wrongdose of HRT over the age of 60. In women who started below theage of 60 there were fewer heart attacks, fewer deaths, fewerosteoporotic fractures and even less breast cancer in this study.It is probable that the one residual side-effect is a small1% extra lifetime risk of developing breast cancer, but thisis no more than the breast cancer risk of being overweight,drinking wine, having no children or even taking statins. {DISAGREE: As above stated the author




High levels of Estrogen Can cause depression

High levels of Estrogen Can cause depression

Estrogen and Depression

The sex difference in rates of psychiatric illness beginning at puberty and continuing throughout the reproductive years suggest that the brain’s hormonal environment is the thing which modulate the risk and severity of psychiatric morbidity. Hormones play an integral role in the development and prognosis of psychiatric disorders has been increasing attention, especially along with depression treatment. The male-female contrasts in estrogen production throughout the reproductive years are responsible for the modulating the expression of depression between the sexes. Change in mood reported during the late luteal phase of the menstrual cycle and following childbirth mainly.

There are so many causes of increase in the rate of depression at the time of menopause and the recent research for it does not found any evidence that explain that the major depression increases after menopause, at a time when estrogen levels decline. But the thing is observed that post-menopausal women are increasingly vulnerable to depression as the estrogen production reduces in them. Actually the action of estrogen on neurotransmitter and receptor functioning are having the antidepressant symptoms. The main aim of estrogen is to enhance serotonergic functions like increases synthesis and uptake, post-synaptic receptor responsivity, and leads to up-regulation of 5-HT1 and down-regulation of 5-HT2 serotonin receptors.

Estrogen also increases norepinephrine activity in the brain which are responsible for improving the mood and cognition reported in women on estrogen replacement therapy (ERT) and it also involves changes in monoamine oxidase activity. In non-depressed peri- and post-menopausal women though estrogen has been known to improve mood and sense of well being, estrogen alone but it does not improve mood in women with clinical depression. Estrogen as an adjunct to antidepressant therapy is also helpful.

Recently it is researched that the older depressed women in the age 60 years or more older on ERT who received sertraline had substantially improved well than women receiving sertraline alone. Estrogen augmentation for perimenopausal depression be reserved for a subgroup of women, those suffering from depression like postpartum depression or mood changes related to the menstrual cycle associated with changes in estrogen levels. There is a link between Estrogens and the onset, course and severity of depression suggesting estrogen supplementation may be a useful adjuvant therapy in selected depressed women.

Estrogen Source of Stress

As the survey on depression itself suggest that the stress-related depressions are seen twice in women as compared to men. Estrogens level is the main reason for this happening. Even mild levels of stress which don’t affect men, can affect female very easily as their estrogen levels were elevated as estrogen makes the brain more vulnerable to stress. High levels of estrogen increases brain’s response to stress which is responsible that women are more vulnerable to mental illnesses such as depression and post-traumatic stress disorder (PTSD) than men.

It is known that estrogen can interact with molecular processes involved in the stress response and that certain genetic variations have been demonstrated in clinically depressed women. But how these factors combine to produce the disparity in the prevalence of this disorder is unknown




Red yeast rice

Red yeast rice

Red yeast rice (RYR), a product made from cultivating rice with the mold Monascus purpureus, has been used in China for centuries to treat circulatory and digestive disorders – and apparently without a bit of controversy. RYR has been in use in the U.S. for a much shorter period of time (as a non-prescription cholesterol-lowering supplement), and has generated lots of controversy.

The Controversy and Confusion Over RYR

The controversy began in 1999, shortly after clinical trials first showed that RYR could indeed significantly lower cholesterol levels. At that time it came to the attention of the FDA that RYR’s effectiveness is related to the fact that it contains a naturally-occurring form of the statin drug lovastatin (marketed as Mevacor). So the FDA ruled that RYR was a regulable drug, and thus ordered it removed it from the shelves.

This FDA decision was initially overruled by the District Court of Utah in 1999, but in 2000 the 10th U.S. Circuit Court of Appeals agreed with the FDA that RYR could be regulated. So RYR could still be sold legally in the U.S., but only if steps were taken in its manufacturing process to remove the lovastatin (presumably eliminating its effectiveness).

Then, in 2007, the FDA found that at least some RYR in the U.S. still contained lovastatin, and (after issuing a formal FDA Consumer Safety Alert) took further steps to purge the “tainted” products from the shelves.

Currently, as far as the FDA is concerned, the RYR that you can buy in the U.S. contains no lovastatin. But otherwise, RYR is still considered a dietary supplement, so its formulation and content is still not regulated — and it is very difficult if not impossible to find out what it does contain. (This is the case with any unregulated dietary supplement.)

But Does It Work?

In the face of all this confusion, two clinical trials have appeared in the last few years that show that at least some RYR legally available in the U.S. is still effective in reducing cholesterol levels.

In 2009, a study from Pennsylvania showed that in 60 patients who had to stop taking statin drugs because of muscle pain, taking RYR and initiating lifestyle changes for 24 weeks significantly reduced total and LDL cholesterol levels, compared to taking a placebo and making the same lifestyle changes.

And in 2010, investigators from the University of Pennsylvania reported that in patients who had to stop taking statins due to muscle pain, RYR was just as effective as 20 mg per day of the statin drug pravastatin (Pravachol) in reducing cholesterol levels. (Both RYR and pravachol produced only a very low incidence of recurrent muscle pain.)

In the 2009 study, the investigators performed a formal chemical analysis on the RYR product they used in their study (from Sylvan Bioproducts in Kittanning, Pennsylvania). They found that the RYR contained monacolin K (the naturally-occurring form of lovastatin), as well as eight other monacolins (statins or statin-like substances).

The result of this chemical analysis suggests two things. First, that RYR available in the U.S. apparently still contains at least some lovastatin, and second, even if all the lovastatin were completely removed (which appears to be much harder to do than the FDA thinks) other, similar chemicals in RYR may be effective in reducing cholesterol.




B5 WHY IS IT USED IN ANTI- AGING (ACNE MEDICATION)

B5 WHY IS IT USED IN ANTI- AGING (ACNE MEDICATION)

August 8, 2011

Pantothenic acid is a vitamin, also known as vitamin B5. It is widely found in both plants and animals including meat, vegetables, cereal grains, legumes, eggs, and milk.

Vitamin B5 is commercially available as D-pantothenic acid, as well as dexpanthenol and calcium pantothenate, which are chemicals made in the lab from D-pantothenic acid.

Pantothenic acid is frequently used in combination with other B vitamins in vitamin B complex formulations. Vitamin B complex generally includes vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid. However, some products do not contain all of these ingredients and some may include others, such as biotin, para-aminobenzoic acid (PABA), choline bitartrate, and inositol.

Pantothenic acid has a long list of uses, although there isn’t enough scientific evidence to determine whether it is effective for most of these uses. People take pantothenic acid for treating dietary deficiencies, acne, alcoholism, allergies, baldness, asthma, attention deficit-hyperactivity disorder (ADHD), autism, burning feet syndrome, yeast infections, heart failure, carpal tunnel syndrome, respiratory disorders, celiac disease, colitis, conjunctivitis, convulsions, and cystitis. It is also taken by mouth for dandruff, depression, diabetic nerve pain, enhancing immune function, improving athletic performance, tongue infections, gray hair, headache, hyperactivity, low blood sugar, trouble sleeping (insomnia), irritability, low blood pressure, multiple sclerosis, muscular dystrophy, muscular cramps in the legs associated with pregnancy or alcoholism, neuralgia, and obesity.

Pantothenic acid is also used orally for osteoarthritis, rheumatoid arthritis, Parkinson’s disease, nerve pain, premenstrual syndrome (PMS), enlarged prostate, protection against mental and physical stress and anxiety, reducing adverse effects of thyroid therapy in congenital hypothyroidism, reducing signs of aging, reducing susceptibility to colds and other infections, retarded growth, shingles, skin disorders, stimulating adrenal glands, chronic fatigue syndrome, salicylate toxicity, streptomycin neurotoxicity, dizziness, and wound healing.

People apply dexpanthenol, which is made from pantothenic acid, to the skin for itching, promoting healing of mild eczemas and other skin conditions, insect stings, bites, poison ivy, diaper rash, and acne. It is also applied topically for preventing and treating skin reactions to radiation therapy.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for PANTOTHENIC ACID (VITAMIN B5) are as follows:

Effective for…

  • Treating or preventing pantothenic acid deficiency.

Possibly ineffective for…

  • Treating or preventing skin reactions from radiation therapy.

Insufficient evidence to rate effectiveness for…

  • Attention deficit-hyperactivity disorder (ADHD). There is conflicting evidence regarding the usefulness of pantothenic acid in combination with large doses of other vitamins for the treatment of ADHD.
  • Arthritis. Developing research suggests pantothenic acid (given as calcium pantothenate) does not significantly reduce the symptoms of arthritis in people with rheumatoid arthritis, osteoarthritis, or other forms of arthritis.
  • Improving athletic performance. Some research suggests that pantothenic acid in combination with pantethine and thiamine does not improve muscular strength or endurance in well-trained athletes.
  • Skin problems.
  • Alcoholism.
  • Allergies.
  • Hair loss.
  • Asthma.
  • Heart problems.
  • Carpal tunnel syndrome.
  • Lung disorders.
  • Colitis.
  • Eye infections (conjunctivitis).
  • Convulsions.
  • Kidney disorders.
  • Dandruff.
  • Depression.
  • Diabetic problems.
  • Enhancing immune function.
  • Headache.
  • Hyperactivity.
  • Low blood pressure.
  • Inability to sleep (insomnia).
  • Irritability.
  • Multiple sclerosis.
  • Muscular dystrophy.
  • Muscle cramps.
  • Other conditions.

More evidence is needed to rate the effectiveness of pantothenic acid for these uses.

How does it work?

Pantothenic acid is important for our bodies to properly use carbohydrates, proteins, and lipids and for healthy skin.

Are there safety concerns?

Pantothenic acid is LIKELY SAFE for most people when used in appropriate amounts. The recommended amount for adults is 5 mg per day. Even larger amounts seem to be safe for some people, but taking larger amounts increases the chance of having side effects such as diarrhea.

Pantothenic acid seems to be safe for children when used appropriately.

Special precautions & warnings:

Pregnancy and breast-feeding: Pantothenic acid is LIKELY SAFE when taken in recommended amounts of 6 mg per day during pregnancy and 7 mg per day during breast-feeding. But it is not known if taking more than this amount is safe.

Hemophila: Don’t take pantothenic acid if you have hemophila. It might extend the time it takes for bleeding to stop.

Are there interactions with medications?

It is not known if this product interacts with any medicines.

Before taking this product, talk with your health professional if you take any medications.

Are there interactions with herbs and supplements?

Royal jelly

Royal jelly contains significant amounts of pantothenic acid. The effects of taking royal jelly and pantothenic acid supplements together aren’t known.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research:

BY MOUTH:

  • As a dietary supplement: 5-10 mg of pantothenic acid (vitamin B5).

Recommended daily intakes for pantothenic acid (vitamin B5) are as follows: Infants 0-6 months, 1.7 mg; infants 7-12 months, 1.8 mg; children 1-3 years, 2 mg; children 4-8 years, 3 mg; children 9-13 years, 4 mg; men and women

14 years and older, 5 mg; pregnant women, 6 mg; and breastfeeding women, 7 mg.

Other names

Acide Pantothénique, Ácido Pantoténico, B Complex Vitamin, Calcii Pantothenas, Calcium D-Pantothenate, Calcium Pantothenate, D-Calcium Pantothenate, D-pantothenic Acid, D-Panthenol, D-Pantothenyl Alcohol, Dexpanthenol, Dexpanthenolum, Panthenol, Pantothenate, Pantothenic Acid, Pantothenol, Pantothenylol, Vitamin B5, Vitamin B-5, Vitamina B5, Vitamine B5.




Low Testosterone – what causes it?

Low Testosterone – what causes it?

August 5, 2011

What causes testosterone deficiency?

Testosterone is a hormone produced by the testicles and is responsible for the proper development of male sexual characteristics, and is important for maintaining muscle bulk, adequate levels of red blood cells, bone density, sense of well-being, and sexual and reproductive function.

Inadequate testosterone production is not a common cause of erectile dysfunction (ED). When ED does occur with decreased testosterone production, testosterone replacement therapy may improve the ED.

As a man ages, the amount of testosterone in his body gradually declines. This natural decline starts after age 30 and continues throughout life. The significance of this decline is controversial and poorly understood.

Symptoms of testosterone deficiency:

  • decreased sex drive
  • decreased sense of well-being
  • depressed mood
  • difficulties with concentration and memory
  • erectile dysfunction

What are the changes that occur in the body with testosterone deficiency?

Changes that occur with testosterone deficiency include:

  • a decrease in muscle mass, with an increase in body fat
  • variable effects on cholesterol metabolism
  • a decrease in hemoglobin and possibly mild anemia
  • fragile bones (osteoporosis)
  • a decrease in body hair

How do I find out if I have a testosterone deficiency?

The only accurate way to detect the condition is to have your doctor measure the amount of testosterone in your blood. It sometimes may take several measurements of testosterone to be sure if a patient has a deficiency, since levels of testosterone tend to fluctuate throughout the day. The highest levels of testosterone are generally in the morning. This is why doctors prefer, if possible, to obtain early morning levels of testosterone.

What options are available for testosterone replacement?

The options available for testosterone replacement are:

  • intramuscular injections, generally every two or three weeks
  • testosterone patches worn either on the body or on the scrotum (the sac that contains the testicles). These patches are used daily. The body patch application is rotated between the buttocks, arms, back or abdomen.
  • testosterone gels that are applied daily to the shoulders, upper arms, or abdomen.

For a free consultation on what would work best for you, contact us at:

info@coreinstitutes.com or call us at 866-641-CORE (2673)




Click here to discover
how to slow down the aging process.